SQ 22536

Name: SQ 22536
Brand: Tocris Bioscience
SKU: 1435

Tocris Bioscience, part of Bio-Techne | Catalog # 1435

Citations (121)

COA / SDS

Adenylyl cyclase inhibitor

Key Product Details

Description:	Adenylyl cyclase inhibitor
Chemical Name:	9-(Tetrahydro-2-furanyl)-9H-purin-6-amine
Purity:	≥98% (HPLC)
Molecular Weight:	205.22

View Full Technical Details for SQ 22536

Technical Data
Citations

Biological Activity for SQ 22536

SQ 22536 is an inhibitor of adenylyl cyclase (IC₅₀ = 1.4 μM). Inhibits PGE₁-stimulated increases in cAMP levels in intact human platelets. Cell permeable.

Compound Libraries for SQ 22536

SQ 22536 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SQ 22536

M. Wt	205.22
Formula	C₉H₁₁N₅O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	17318-31-9
PubChem ID	5270
InChi Key	UKHMZCMKHPHFOT-UHFFFAOYSA-N
Smiles	NC1=C2N=CN(C3CCCO3)C2=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SQ 22536

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.26	50

Preparing Stock Solutions for SQ 22536

The following data is based on the product molecular weight 205.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	9.75 mL	48.73 mL	97.46 mL
2.5 mM	1.95 mL	9.75 mL	19.49 mL
5 mM	0.97 mL	4.87 mL	9.75 mL
25 mM	0.19 mL	0.97 mL	1.95 mL

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Reconstitution Calculator

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References for SQ 22536

References are publications that support the biological activity of the product.

Madhavan Induction of myelinating oligodendrocytes in human cortical spheroids. Nat.Methods. 2018 PMID: 30046099
Mei Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis. Nat.Methods. 2014 PMID: 24997607
Harris Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives. J.Cyclic Nucleotide Res. 1979 PMID: 221552
Hourani Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues. Br.J.Pharmacol. 2001 PMID: 11454656
Fabbri Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536). J.Enzyme Inhib. 1991 PMID: 1669444