SPP 86
Tocris Bioscience, part of Bio-Techne | Catalog # 5391
Potent RET inhibitor
Product Description
SPP 86 is a potent RET inhibitor (IC50 = 8 nM). Also exhibits inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. Inhibits proliferation of HCT 116 and TPC1 cells in vitro. Cell permeable.Product Specifications
Molecular Weight
277.32
Formula
C16H15N5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS Number
1357349-91-7
PubChem ID
66549796
InChI Key
JQOIRTDBHMDWMT-UHFFFAOYSA-N
SMILES
CC(C)N1N=C(C#CC3=CC=CC=C3)C2=C1N=CN=C2N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.73 | 100 | |
| Ethanol | 5.55 | 20 |
Preparing Stock Solutions
for SPP 86
The following data is based on the product molecular weight 277.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.61 mL | 18.03 mL | 36.06 mL |
| 5 mM | 0.72 mL | 3.61 mL | 7.21 mL |
| 10 mM | 0.36 mL | 1.80 mL | 3.61 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Klein Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases. PLoS ONE 2011 PMID: 21698101
- Dinér Preparation of 3-substituted-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines as RET kinase inhibitors. J.Med.Chem. 2012 PMID: 22559926
Product Specific Notices for SPP 86
For research use only
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