Spiperone hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0995
5-HT2A antagonist; also D2-like antagonist
Discontinued Product
0995 has been discontinued.
View all 5-HT2A Receptor Antagonists products.
Key Product Details
Description
5-HT2A antagonist; also D2-like antagonist
Product Description
Spiperone hydrochloride is a 5-HT2A serotonin and selective D2-like dopamine receptor antagonist (Ki values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors respectively). Antipsychotic.Product Specifications
Molecular Weight
431.94
Formula
C23H26FN3O2.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride
CAS Number
2022-29-9
PubChem ID
11957687
InChI Key
QUIKMLCZZMOBLH-UHFFFAOYSA-N
SMILES
Cl.FC1=CC=C(C=C1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.19 | 100 |
Preparing Stock Solutions
for Spiperone hydrochloride
The following data is based on the product molecular weight 431.94
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.58 mL | 23.15 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.63 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Seeman and van Tol DA receptor pharmacology. TiPS 1994 PMID: 7940991
- Hoyer VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 1994 PMID: 7938165
Product Specific Notices for Spiperone hydrochloride
For research use only
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