Spermine tetrahydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0958
Modulator at polyamine site
Key Product Details
Description
Modulator at polyamine site
Product Description
Spermine tetrahydrochloride is a polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.Product Specifications
Molecular Weight
348.19
Formula
C10H26N4.4HCl
Storage
Desiccate at +4°C
Chemical Name
N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
CAS Number
306-67-2
PubChem ID
9384
InChI Key
XLDKUDAXZWHPFH-UHFFFAOYSA-N
SMILES
NCCCNCCCCNCCCN.Cl.Cl.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 34.82 | 100 |
Preparing Stock Solutions
for Spermine tetrahydrochloride
The following data is based on the product molecular weight 348.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.87 mL | 14.36 mL | 28.72 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.74 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.87 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Munir Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 1993 PMID: 8358608
- Doyle and Shaw Investigation of the actions and antagonist activity of some polyamine analogues in vivo. Br.J.Pharmacol. 1998 PMID: 9641557
- Johnson Modulation of channel function by polyamines. TiPS 1996 PMID: 8789355
- Benveniste and Mayer Multiple effects of spermine on N-MthD.-aspartic acid receptor responses of rat cultured hippocampal neurones. J.Physiol. 1993 PMID: 8229795
Product Specific Notices for Spermine tetrahydrochloride
For research use only
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