SM-21 maleate
Tocris Bioscience, part of Bio-Techne | Catalog # 0751
Selective σ2 antagonist. Centrally active
Key Product Details
Description
Selective σ2 antagonist. Centrally active
Product Description
SM-21 maleate is a potent and selective σ2 antagonist with central effects following systemic administration. Causes increased release of acetylcholine at central muscarinic synapses. Potent analgesic (efficacy comparable to morphine) and nootropic agent.Product Specifications
Molecular Weight
453.92
Formula
C18H24ClNO3.C4H4O4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(±)-Tropanyl 2-(4-chlorophenoxy)butanoate maleate
CAS Number
155059-42-0
PubChem ID
11691005
InChI Key
BHXGTFUQDGMXHA-BTJKTKAUSA-N
SMILES
OC(=O)\C=C/C(O)=O.CCC(OC1=CC=C(Cl)C=C1)C(=O)OC1CC2CCC(C1)N2C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.35 | 25 |
Preparing Stock Solutions
for SM-21 maleate
The following data is based on the product molecular weight 453.92
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 8.81 mL | 44.06 mL | 88.12 mL |
| 1.25 mM | 1.76 mL | 8.81 mL | 17.62 mL |
| 2.5 mM | 0.88 mL | 4.41 mL | 8.81 mL |
| 12.5 mM | 0.18 mL | 0.88 mL | 1.76 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ghelardini Pharmacological identification of SM-21, the novel σ2 antagonist. Pharmacol.Biochem.Behav. 2000 PMID: 11164098
- Matsumoto and Mack (±)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice. Eur.J.Pharmacol. 2001 PMID: 11301071
- Ghelardini Antinociceptive profile of 3-α-tropanyl-(2-Cl)-acid phenoxybutyrate (SM-21): a novel analgesic with a presynaptic cholinergic mechanism of action. J.Pharmacol.Exp.Ther. 1997 PMID: 9223584
Product Specific Notices for SM-21 maleate
For research use only
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