SKF 96365 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1147
TRPC channel inhibitor; also inhibits store-operated Ca2+ entry
Key Product Details
Description
TRPC channel inhibitor; also inhibits store-operated Ca2+ entry
Product Description
SKF 96365 hydrochloride is a store-operated Ca2+ entry (SOCE) inhibitor that inhibits STIM1. Also blocks TRPC channels, voltage-gated Ca2+ channels and potassium channels.Product Specifications
Molecular Weight
402.92
Formula
C22H26N2O3.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl-1H-imidazole hydrochloride
CAS Number
130495-35-1
PubChem ID
104955
InChI Key
FWLPKVQUECFKSW-UHFFFAOYSA-N
SMILES
Cl.COC1=CC=C(CCCOC(CN2C=CN=C2)C2=CC=C(OC)C=C2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.06 | 20 with gentle warming |
Preparing Stock Solutions
for SKF 96365 hydrochloride
The following data is based on the product molecular weight 402.92
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.41 mL | 62.05 mL | 124.09 mL |
| 1 mM | 2.48 mL | 12.41 mL | 24.82 mL |
| 2 mM | 1.24 mL | 6.20 mL | 12.41 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Varnai STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 2009 PMID: 19187978
- Singh The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels. Br.J.Pharmacol. 2010 PMID: 20590636
- Merritt SK&F96365, a novel inhibitor of receptor-mediated calcium entry. Biochem.J. 1990 PMID: 2173565
Product Specific Notices for SKF 96365 hydrochloride
For research use only
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