SK 216

Name: SK 216
Brand: Tocris Bioscience
SKU: 6187

Tocris Bioscience, part of Bio-Techne | Catalog # 6187

COA / SDS

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

Key Product Details

Description:	Plasminogen activator inhibitor-1 (PAI-1) inhibitor
Chemical Name:	2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]propanedioic acid disodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	533.52

View Full Technical Details for SK 216

Technical Data
Citations

Biological Activity for SK 216

SK 216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor. Inhibits VEGF-induced migration and tube formation in HUVECs. Also attenuates TGF-β dependent epithelial-mesenchymal transition and fibroblast to myofibroblast differentiation in vitro. Reduces size and weight of subcutaneous tumors, and inhibits metastasis and angiogenesis in vivo. Reduces bleomycin-induced pulmonary fibrosis in vivo. Orally bioavailable.

Technical Data for SK 216

M. Wt	533.52
Formula	C₂₉H₂₉NO₆Na₂
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	654080-03-2
PubChem ID	131954585
InChi Key	YYTGMMYYLGKWIK-UHFFFAOYSA-L
Smiles	CC(C)(C)C1=CC=C(OC(C2=CC(C=CC(OCCCCCC(C(O[Na])=O)C(O[Na])=O)=C3)=C3C=C2)=N4)C4=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SK 216

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	2.67	5 with gentle warming

Preparing Stock Solutions for SK 216

The following data is based on the product molecular weight 533.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	37.49 mL	187.43 mL	374.87 mL
0.25 mM	7.50 mL	37.49 mL	74.97 mL
0.5 mM	3.75 mL	18.74 mL	37.49 mL
2.5 mM	0.75 mL	3.75 mL	7.50 mL

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References for SK 216

References are publications that support the biological activity of the product.

Takayama Inhibition of PAI-1 limits tumor angiogenesis regardless of angiogenic stimuli in malignant pleural mesothelioma. Cancer Res. 2016 PMID: 27197170
Masuda SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis. Mol.Cancer Ther. 2013 PMID: 23990114
Omori Inhibition of plasminogen activator inhibitor-1 attenuates transforming growth factor-β-dependent epithelial mesenchymal transition and differentiation of fibroblasts to myofibroblasts. PLoS One. 2016 PMID: 26859294