SJF 8240

Tocris Bioscience, part of Bio-Techne | Catalog # 7266

c-MET PROTAC®; also degrades exon-14-deleted c-MET
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Key Product Details

Description

c-MET PROTAC®; also degrades exon-14-deleted c-MET

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Product Description

SJF 8240 is a c-MET PROTAC® Degrader. Comprises MET inhibitor foretinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells.

c-MET antibodies validated for Western Blot also available: Catalog # AF276 and MAB5694.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications

Molecular Weight

1106.25

Formula

C58H65F2N7O11S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(3-Fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

CAS Number

2230821-68-6

PubChem ID

135175904

InChI Key

SCUZPTNDZHEHLB-ZWUDBOSPSA-N

SMILES

COC1=CC2=C(N=CC=C2OC3=C(C=C(C=C3)NC(C4(C(NC5=CC=C(C=C5)F)=O)CC4)=O)F)C=C1OCCCOCCCOCCC(N[C@@H](C(C)(C)C)C(N6C[C@@H](C[C@H]6C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.31 50

Preparing Stock Solutions for SJF 8240

The following data is based on the product molecular weight 1106.25

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 1.81 mL 9.04 mL 18.08 mL
2.5 mM 0.36 mL 1.81 mL 3.62 mL
5 mM 0.18 mL 0.90 mL 1.81 mL
25 mM 0.04 mL 0.18 mL 0.36 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SJF 8240

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SJF 8240

For research use only

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