Sivelestat sodium salt

Name: Sivelestat sodium salt
Brand: Tocris Bioscience
SKU: 3535

Tocris Bioscience, part of Bio-Techne | Catalog # 3535

Citations (12)

COA / SDS

Selective leukocyte elastase inhibitor

Key Product Details

Description:	Selective leukocyte elastase inhibitor
Alternative Names:	ONO-5046
Chemical Name:	N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	456.44

View Full Technical Details for Sivelestat sodium salt

Technical Data
Citations

Biological Activity for Sivelestat sodium salt

Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC₅₀ = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB₄-induced neutrophil transmigration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo.

Compound Libraries for Sivelestat sodium salt

Sivelestat sodium salt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Sivelestat sodium salt

M. Wt	456.44
Formula	C₂₀H₂₁N₂NaO₇S
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	150374-95-1
PubChem ID	23664980
InChi Key	ZAIFANJZUGNYCK-UHFFFAOYSA-M
Smiles	[Na+].CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC=C1C(=O)NCC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sivelestat sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.82	50

Preparing Stock Solutions for Sivelestat sodium salt

The following data is based on the product molecular weight 456.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.38 mL	21.91 mL	43.82 mL
2.5 mM	0.88 mL	4.38 mL	8.76 mL
5 mM	0.44 mL	2.19 mL	4.38 mL
25 mM	0.09 mL	0.44 mL	0.88 mL

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References for Sivelestat sodium salt

References are publications that support the biological activity of the product.

Iwamoto Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury. Interact.Cardiovasc.Thorac.Surg. 2009 PMID: 19289399
Young Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice. Br.J.Pharmacol. 2007 PMID: 17471175
Hagiwara Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-κB. Inflamm.Res. 2009 PMID: 19169649
Kawabata ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem.Biophys.Res.Commun. 1991 PMID: 2049103