SI-2 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5964

Steroid receptor coactivator 3 (SRC-3) inhibitor
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Key Product Details

Description

Steroid receptor coactivator 3 (SRC-3) inhibitor

View all Other Nuclear Receptor Compounds »

Product Description

SI-2 hydrochloride is a potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.

Product Specifications

Molecular Weight

301.78

Formula

C15H15N5.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride

CAS Number

1992052-49-9

PubChem ID

121513909

InChI Key

CDYJHORKRVKALB-NWBUNABESA-N

SMILES

CN1C(N/N=C(C2=CC=CC=N2)\C)=NC3=CC=CC=C13.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 15.09 50
DMSO 6.04 20

Preparing Stock Solutions for SI-2 hydrochloride

The following data is based on the product molecular weight 301.78

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.63 mL 33.14 mL 66.27 mL
2.5 mM 1.33 mL 6.63 mL 13.25 mL
5 mM 0.66 mL 3.31 mL 6.63 mL
25 mM 0.13 mL 0.66 mL 1.33 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for SI-2 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SI-2 hydrochloride

For research use only

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