SHIN 1
Tocris Bioscience, part of Bio-Techne | Catalog # 6998
Potent SHMT inhibitor
Product Description
SHIN 1 is a potent serine hydroxymethyltransferase (SHMT) inhibitor (IC50 values are 5 and 13 nM at SHMT1 and SHMT2, respectively). Inhibits growth of HCT-116 cells in vitro (IC50 = 870 nM). Unstable in liver microsome assays.Licensing Information
Sold under license from Princeton University.Product Specifications
Molecular Weight
400.48
Formula
C24H24N4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile
CAS Number
2146095-85-2
PubChem ID
134335083
InChI Key
VVVOFJZXKJKHTD-UHFFFAOYSA-N
SMILES
CC(C1(C2=CC(C3=CC=CC=C3)=CC(CO)=C2)C4=C(OC(N)=C1C#N)NN=C4C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.02 | 50 |
Preparing Stock Solutions
for SHIN 1
The following data is based on the product molecular weight 400.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.99 mL | 24.97 mL | 49.94 mL |
| 2.5 mM | 1.00 mL | 4.99 mL | 9.99 mL |
| 5 mM | 0.50 mL | 2.50 mL | 4.99 mL |
| 25 mM | 0.10 mL | 0.50 mL | 1.00 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ducker Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc.Natl.Acad.Sci.U.S.A. 2017 PMID: 29073064
Product Specific Notices for SHIN 1
For research use only
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