SGX 523
Tocris Bioscience, part of Bio-Techne | Catalog # 5356
Selective and potent c-MET kinase inhibitor
Key Product Details
Description
Selective and potent c-MET kinase inhibitor
Product Description
SGX 523 is a potent and selective c-MET kinase inhibitor (IC50 = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μM). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGX 523 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
359.41
Formula
C18H13N7S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline
CAS Number
1022150-57-7
PubChem ID
24779724
InChI Key
BCZUAADEACICHN-UHFFFAOYSA-N
SMILES
CN1N=CC(C(C=C2)=NN3C2=NN=C3SC4=CC5=CC=CN=C5C=C4)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.19 | 20 |
Preparing Stock Solutions
for SGX 523
The following data is based on the product molecular weight 359.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.91 mL | 69.56 mL | 139.12 mL |
| 1 mM | 2.78 mL | 13.91 mL | 27.82 mL |
| 2 mM | 1.39 mL | 6.96 mL | 13.91 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.78 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Buchanan SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol.Cancer.Ther. 2009 PMID: 19934279
Product Specific Notices for SGX 523
For research use only
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