SGC UBD253 New
Tocris Bioscience, part of Bio-Techne | Catalog # 8074
Potent and selective HDAC6-UBD antagonist; does not inhibit HDAC6 catalytic activity
Key Product Details
Description
Potent and selective HDAC6-UBD antagonist; does not inhibit HDAC6 catalytic activity
Product Description
SGC UBD253 is a potent and selective histone deacetylase 6 (HDAC6-UBD) antagonist (KD = 80 nM, 84 nM and 95 nM determined by ITC, SPR and FP, respectively, for the UBD domain; KD = 0.26 μM and 0.44 μM determined by SPR and FP, respectively, for full length HDAC6). Displays 50-fold selectivity for HDAC6 over other UBD proteins, with the exception of USP16 (15-fold). In live cells, it significantly decreases the interaction between HDAC6 and ISG15 (EC50 = 1.9 μM in a NanoBRET assay). Treatment with SGC UBD253 does not inhibit the catalytic activity of HDAC6.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC UBD253 probe summary on the SGC website.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC UBD253 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
429.86
Formula
C21H20ClN3O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-(8-Chloro-3-(2-((2-methoxybenzyl)amino)-2-oxoethyl)-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid
CAS Number
3033200-03-9
PubChem ID
164946806
InChI Key
YLHSFRZHEMHKAF-UHFFFAOYSA-N
SMILES
O=C1C2=CC=CC(Cl)=C2N=C(N1CC(NCC3=CC=CC=C3OC)=O)CCC(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 0.43 | 1 |
Preparing Stock Solutions
for SGC UBD253
The following data is based on the product molecular weight 429.86
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.01 mM | 232.63 mL | 1,163.17 mL | 2,326.34 mL |
| 0.05 mM | 46.53 mL | 232.63 mL | 465.27 mL |
| 0.1 mM | 23.26 mL | 116.32 mL | 232.63 mL |
| 0.5 mM | 4.65 mL | 23.26 mL | 46.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Harding Discovery and characterization of a chemical probe targeting the zinc-finger ubiquitin-binding domain of HDAC6. J.Med.Chem. 2023 PMID: 37499118
Product Specific Notices for SGC UBD253
For research use only
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