SGC GAK 1

Name: SGC GAK 1
Brand: Tocris Bioscience
SKU: 6564

Tocris Bioscience, part of Bio-Techne | Catalog # 6564

Citations (1)

COA / SDS

High affinity cyclin G associated kinase (GAK) inhibitor

Key Product Details

Description:	High affinity cyclin G associated kinase (GAK) inhibitor
Chemical Name:	6-Bromo-N-(3,4,5-trimethoxyphenyl)-4-quinolinamine
Purity:	≥98% (HPLC)
Molecular Weight:	389.24

View Full Technical Details for SGC GAK 1

Technical Data
Citations

Biological Activity for SGC GAK 1

SGC GAK 1 is a high affinity cyclin G associated kinase (GAK) inhibitor (K_d = 1.9 nM). Exhibits >30-fold selectivity for GAK over a panel of other kinases. Inhibits GAK in live cell assays (IC₅₀ = 110 nM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC GAK 1 probe summary on the SGC website.

Compound Libraries for SGC GAK 1

SGC GAK 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SGC GAK 1

M. Wt	389.24
Formula	C₁₈H₁₇BrN₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2226517-76-4
PubChem ID	50877865
InChi Key	JVUVMZJTEXYQNS-UHFFFAOYSA-N
Smiles	BrC1=CC2=C(NC3=CC(OC)=C(OC)C(OC)=C3)C=CN=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SGC GAK 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.92	100
	ethanol	19.46	50

Preparing Stock Solutions for SGC GAK 1

The following data is based on the product molecular weight 389.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.85 mL	25.69 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.28 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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Reconstitution Calculator

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References for SGC GAK 1

References are publications that support the biological activity of the product.

Asquith Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK). Bioorg.Med.Chem.Lett. 2019 PMID: 31129055
Asquith SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK). J.Med.Chem. 2019 PMID: 30768268