SET 2

Name: SET 2
Brand: Tocris Bioscience
SKU: 6990

Tocris Bioscience, part of Bio-Techne | Catalog # 6990

Citations (8)

COA / SDS

Selective TRPV2 antagonist

Key Product Details

Description:	Selective TRPV2 antagonist
Chemical Name:	N-(2-Furanylmethyl)-3-[[4-(methylpropylamino)-6-(trifluoromethyl)-2-pyrimidinyl]thio]propanamide
Purity:	≥98% (HPLC)
Molecular Weight:	402.44

View Full Technical Details for SET 2

Technical Data
Citations

Biological Activity for SET 2

SET 2 is a TRPV2 (transient receptor potential vanilloid type 2) antagonist (IC₅₀ = 0.46 μM). Selective for TRPV2 over TRPV1, TRPV3 and TRPV4 expressed in HEK293 cells. Inhibits lyosphosphatidic acid (LPA)-induced prostate cancer cell migration in vitro.

Compound Libraries for SET 2

SET 2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SET 2

M. Wt	402.44
Formula	C₁₇H₂₁F₃N₄O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2313525-20-9
InChi Key	LZHSWRWIMQRTOP-UHFFFAOYSA-N
Smiles	CCCN(C1=NC(SCCC(NCC2=CC=CO2)=O)=NC(C(F)(F)F)=C1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SET 2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.24	100
	ethanol	20.12	50

Preparing Stock Solutions for SET 2

The following data is based on the product molecular weight 402.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.48 mL	12.42 mL	24.85 mL
5 mM	0.50 mL	2.48 mL	4.97 mL
10 mM	0.25 mL	1.24 mL	2.48 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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Reconstitution Calculator

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References for SET 2

References are publications that support the biological activity of the product.

Chai Structure-based discovery of a subtype-selective inhibitor targeting a transient receptor potential vanilloid channel. J.Med.Chem. 2019 PMID: 30620187