Sephin 1
Tocris Bioscience, part of Bio-Techne | Catalog # 5553
Inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1
Key Product Details
Description
Inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1
Product Description
Sephin 1 is an inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1. Does not bind PPP1R15B or have α2 adrenergic agonist activity. Cytoprotective in endoplasmic reticulum stressed cells in vitro. Prevents defects associated with protein misfolding in a mouse Charcot-Marie Tooth-1B model. Orally available.Product Specifications
Molecular Weight
258.66
Formula
C8H9ClN4.CH2O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2E)-2-[(2-Chlorophenyl)methylene]-hydrazinecarboximidamide carbonic acid salt
CAS Number
1883549-35-6
PubChem ID
121513868
InChI Key
LCQVFBONUDQAEH-NKPNRJPBSA-N
SMILES
ClC1=C(/C=N/NC(N)=N)C=CC=C1.OC(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.87 | 100 |
Preparing Stock Solutions
for Sephin 1
The following data is based on the product molecular weight 258.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.87 mL | 19.33 mL | 38.66 mL |
| 5 mM | 0.77 mL | 3.87 mL | 7.73 mL |
| 10 mM | 0.39 mL | 1.93 mL | 3.87 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.77 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Das Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 2015 PMID: 25859045
Product Specific Notices for Sephin 1
For research use only
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