SEA 0400

Name: SEA 0400
Brand: Tocris Bioscience
SKU: 6164

Tocris Bioscience, part of Bio-Techne | Catalog # 6164

Citations (20)

COA / SDS

Potent Na+/Ca2+ exchanger (NCX) inhibitor

Discontinued Product

6164 has been discontinued. View all Na+/Ca2+ Exchanger Inhibitors products.

Key Product Details

Description:	Potent Na⁺/Ca²⁺ exchanger (NCX) inhibitor
Chemical Name:	2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine
Purity:	≥98% (HPLC)
Molecular Weight:	371.38

View Full Technical Details for SEA 0400

Technical Data
Citations

Biological Activity for SEA 0400

SEA 0400 is a potent Na⁺/Ca²⁺ exchanger (NCX) inhibitor. Inhibits NCX activity in rat astrocytes, microglia and cultured neurons, canine cardiac sarcolemmal vesicles and rat cardiomyocytes (IC₅₀ values are 5 and 8.3, 33, 90 and 92 nM, respectively). Reduces infarct volumes and exhibits protective effects against myocardial ischemia in rats.

Compound Libraries for SEA 0400

SEA 0400 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SEA 0400

M. Wt	371.38
Formula	C₂₁H₁₉F₂NO₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	223104-29-8
PubChem ID	644100
InChi Key	YSUBLPUJDOWYDP-UHFFFAOYSA-N
Smiles	CCOC1=CC(N)=C(C=C1)OC2=CC=C(C=C2)OCC3=C(C=CC(F)=C3)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SEA 0400

References are publications that support the biological activity of the product.

Christ Block of Na(⁺)/Ca(²⁺) exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation. Eur.J.Pharmacol. 2016 PMID: 27373849
Karashima Involvement of Na⁺-Ca²⁺ exchanger in cAMP-mediated relaxation in mice aorta: evaluation using transgenic mice. Br.J.Pharmacol. 2007 PMID: 17220909
Takahashi Protective effects of SEA0400, a novel and selective inhibitor of the Na⁺/Ca²⁺ exchanger, on myocardial ischemia-reperfusion injuries. Eur.J.Pharmacol. 2003 PMID: 12498920