SDZ NKT 343

Tocris Bioscience, part of Bio-Techne | Catalog # 2394

Highly selective human NK1 antagonist
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Key Product Details

Description

Highly selective human NK1 antagonist

View all NK1 Receptor Antagonists »

Product Description

SDZ NKT 343 is a highly selective human tachykinin NK1 receptor antagonist (IC50 values are 0.62 and 451 nM for human and rat receptors respectively) that displays > 130-fold selectivity over human NK2 and NK3 receptors. Potently antagonizes SP-induced Ca2+ efflux in vitro and inhibits mechanical hyperalgesia in vivo.

Product Specifications

Molecular Weight

579.65

Formula

C33H33N5O5

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide

CAS Number

180046-99-5

PubChem ID

9851211

InChI Key

PCVSIMQAFWRUEC-JDXGNMNLSA-N

SMILES

O=C(NC3=C([N+]([O-])=O)C=CC=C3)N1[C@H]([C@@](N[C@H]([C@@](N(C)CC4=CC=CC=C4)=O)CC2=CC=C(C=CC=C5)C5=C2)=O)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 57.97 100
Ethanol 57.97 100

Preparing Stock Solutions for SDZ NKT 343

The following data is based on the product molecular weight 579.65

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.73 mL 8.63 mL 17.25 mL
5 mM 0.35 mL 1.73 mL 3.45 mL
10 mM 0.17 mL 0.86 mL 1.73 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

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Product Documents for SDZ NKT 343

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SDZ NKT 343

For research use only

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