SD 1008
Tocris Bioscience, part of Bio-Techne | Catalog # 3035
JAK2/STAT3 signaling pathway inhibitor
Product Description
SD 1008 is a JAK2/STAT3 signaling pathway inhibitor. Inhibits activation of STAT3, JAK2 and Src. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.Product Specifications
Molecular Weight
329.35
Formula
C18H19NO5
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(1R,5R,6R,7S)-rel-4-Oxo-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid 6,7-dimethyl ester
CAS Number
960201-81-4
PubChem ID
90488795
InChI Key
XJLVVXLRQMISCS-ROINDZCWSA-N
SMILES
O=C1C=C[C@@H]2[C@@H]([C@](OC)=O)[C@@H]([C@](OC)=O)[C@H]1N2CC3=CC=CC=C3.O=C4C=C[C@H]5[C@H](C(OC)=O)[C@H](C(OC)=O)[C@@H]4N5CC6=CC=CC=C6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.94 | 100 | |
| Ethanol | 1.65 | 5 |
Preparing Stock Solutions
for SD 1008
The following data is based on the product molecular weight 329.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.04 mL | 15.18 mL | 30.36 mL |
| 5 mM | 0.61 mL | 3.04 mL | 6.07 mL |
| 10 mM | 0.30 mL | 1.52 mL | 3.04 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for SD 1008
For research use only
Loading...
Loading...