SCR7 pyrazine

Tocris Bioscience, part of Bio-Techne | Catalog # 5342

Enhances HDR efficiency
Discontinued Product
5342 has been discontinued. View all CRISPR Reagents products.

Key Product Details

Description

Enhances HDR efficiency

View all CRISPR Reagents »

Product Description

SCR7 pyrazine enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ).

We have discovered that the commercially available SCR7 material supplied by other vendors does not match the chemical structure that it is being sold under. Through detailed chemical analysis carried out by our Analytical Quality Control experts, we believe that the commercially available SCR7 material, including that used in recent publications to enhance CRISPR efficiency, is in fact an analog of SCR7 that we have named 'SCR7 pyrazine'.

View more information regarding the structure of SCR7.

Product Specifications

Molecular Weight

332.38

Formula

C18H12N4OS

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone

CAS Number

14892-97-8

PubChem ID

10688007

InChI Key

GSRTWXVBHGOUBU-UHFFFAOYSA-N

SMILES

O=C(C(N=C(C3=CC=CC=C3)C(C4=CC=CC=C4)=N2)=C2N1)NC1=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.44 100
Ethanol 6.69 20

Preparing Stock Solutions for SCR7 pyrazine

The following data is based on the product molecular weight 332.38

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.04 mL 30.09 mL
5 mM 0.60 mL 3.01 mL 6.02 mL
10 mM 0.30 mL 1.50 mL 3.01 mL
50 mM 0.06 mL 0.30 mL 0.60 mL

Calculators

Molarity Calculator

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Dilution Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for SCR7 pyrazine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SCR7 pyrazine

For research use only

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