SCH 50911

Name: SCH 50911
Brand: Tocris Bioscience
SKU: 0984

Tocris Bioscience, part of Bio-Techne | Catalog # 0984

Citations (116)

COA / SDS

Selective and competitive GABAB antagonist; orally bioavailable

Key Product Details

Description:	Selective and competitive GABA_B antagonist; orally bioavailable
Chemical Name:	(2S)-(+)-5,5-Dimethyl-2-morpholineacetic acid
Purity:	≥98%
Molecular Weight:	173.21

View Full Technical Details for SCH 50911

Technical Data
Citations

Biological Activity for SCH 50911

SCH 50911 is a selective, competitive and orally active GABA_B antagonist. Displays an IC₅₀ of 1.1 μM at GABA_B, approximately 60 times that of CGP 35348 (Cat. No. 1245) and no binding affinity for GABA_A at concentrations up to 100 μM.

Licensing Information

Sold with the permission of Schering Plough Corporation

Technical Data for SCH 50911

M. Wt	173.21
Formula	C₈H₁₅NO₃
Storage	Desiccate at -20°C
Purity	≥98%
CAS Number	733717-87-8
PubChem ID	5311429
InChi Key	SEYCKMQSPUVYEF-LURJTMIESA-N
Smiles	[H][C@]1(CC(O)=O)CNC(C)(C)CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SCH 50911

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	17.32	100
	phosphate buffered saline	17.32	100

Preparing Stock Solutions for SCH 50911

The following data is based on the product molecular weight 173.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.77 mL	28.87 mL	57.73 mL
5 mM	1.15 mL	5.77 mL	11.55 mL
10 mM	0.58 mL	2.89 mL	5.77 mL
50 mM	0.12 mL	0.58 mL	1.15 mL

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Reconstitution Calculator

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References for SCH 50911

References are publications that support the biological activity of the product.

Blythin Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and related compounds as novel GABA_B antagonists. Bioorg.Med.Chem.Lett.
Hosford Characterization of the antiabsence effects of SCH 50911, a GABA_B receptor antagonist, in the lethargic mouse, γ-hydroxybutyrate, and pentylenetetrazole models. J.Pharmacol. Exp.Ther. 1995 PMID: 7562514
Ong The morpholino-acetic acid analogue Sch 50911 is a selective GABA_B receptor antagonist in rat neocortical slices. Eur.J.Pharmacol. 1998 PMID: 9865527
Bolser The pharmacology of SCH 50911: a novel, orally active GABA-B receptor antagonist. J.Pharmacol.Exp.Ther. 1995 PMID: 7562513