SCH 336

Tocris Bioscience, part of Bio-Techne | Catalog # 5815

COA / SDS

Highly potent and selective CB2 inverse agonist

Key Product Details

Description:	Highly potent and selective CB₂ inverse agonist
Chemical Name:	N-[(1S)-1-[4-[[4-Methoxy-2-[(4-methoxyphenyl)sulfonyl]phenyl]sulfonyl]phenyl]ethyl]methanesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	539.64

View Full Technical Details for SCH 336

Technical Data
Citations

Biological Activity for SCH 336

SCH 336 is a highly potent and selective CB₂ receptor inverse agonist (K_i = 1.8 nM, EC₅₀ = 2 nM). Displays 100-fold selectivity for CB₂ receptors over CB₁. Increases Forskolin stimulated cAMP accumulation in CHO cells expressing human CB₂ receptors. Inhibits leukocyte migration in a murine model of delayed-type hypersensitivity and inhibits antigen-induced lung eosinophilia in a mouse allergy model.

Compound Libraries for SCH 336

SCH 336 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SCH 336

M. Wt	539.64
Formula	C₂₃H₂₅NO₈S₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	447459-51-0
PubChem ID	10324989
InChi Key	NXODIUKWAVUFGF-INIZCTEOSA-N
Smiles	CS(N[C@@H](C)C1=CC=C(S(C2=C(S(=O)(C3=CC=C(OC)C=C3)=O)C=C(OC)C=C2)(=O)=O)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SCH 336

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	53.96	100

Preparing Stock Solutions for SCH 336

The following data is based on the product molecular weight 539.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.27 mL	18.53 mL
5 mM	0.37 mL	1.85 mL	3.71 mL
10 mM	0.19 mL	0.93 mL	1.85 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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Reconstitution Calculator

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References for SCH 336

References are publications that support the biological activity of the product.

Lunn A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J.Pharmacol.Exp.Ther. 2006 PMID: 16258021