SC 79

Tocris Bioscience, part of Bio-Techne | Catalog # 4635

COA / SDS

Akt activator

Key Product Details

Description:	Akt activator
Chemical Name:	2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
Molecular Weight:	364.78

View Full Technical Details for SC 79

Technical Data
Citations

Biological Activity for SC 79

SC 79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.

Technical Data for SC 79

M. Wt	364.78
Formula	C₁₇H₁₇ClN₂O₅
Storage	Store at -20°C
CAS Number	305834-79-1
PubChem ID	2810830
InChi Key	DXVKFBGVVRSOLI-UHFFFAOYSA-N
Smiles	NC2=C(C(OCC)=O)C(C(C(OCC)=O)C#N)C1=CC(Cl)=CC=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SC 79

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.48	100

Preparing Stock Solutions for SC 79

The following data is based on the product molecular weight 364.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.71 mL	27.41 mL
5 mM	0.55 mL	2.74 mL	5.48 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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Reconstitution Calculator

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References for SC 79

References are publications that support the biological activity of the product.

Jo Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc.Natl.Acad.Sci.USA 2012 PMID: 22689977