SC 560

Tocris Bioscience, part of Bio-Techne | Catalog # 1550

Cyclooxygenase-1 (COX-1) inhibitor
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Key Product Details

Description

Cyclooxygenase-1 (COX-1) inhibitor

View all Cyclooxygenase Inhibitors »

Product Description

SC 560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo. Orally active.

Product Specifications

Molecular Weight

352.74

Formula

C17H12ClF3N2O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole

CAS Number

188817-13-2

PubChem ID

4306515

InChI Key

PQUGCKBLVKJMNT-UHFFFAOYSA-N

SMILES

COC1=CC=C(C=C1)N1N=C(C=C1C1=CC=C(Cl)C=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.27 100
Ethanol 8.82 25

Preparing Stock Solutions for SC 560

The following data is based on the product molecular weight 352.74

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.17 mL 28.35 mL
5 mM 0.57 mL 2.83 mL 5.67 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for SC 560

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SC 560

For research use only

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