SC 19220
Tocris Bioscience, part of Bio-Techne | Catalog # 1206
Selective EP1 receptor antagonist
Key Product Details
Description
Selective EP1 receptor antagonist
Product Description
SC 19220 is a selective EP1 receptor antagonist (IC50 = 6.7 μM for inhibition of [3H]-PGE2 binding to EP1 transfected COS cells).Product Specifications
Molecular Weight
331.76
Formula
C16H14ClN3O3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
8-Chloro-dibenzo(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide
CAS Number
19395-87-0
PubChem ID
4336830
InChI Key
KNURFLJTOUGOOQ-UHFFFAOYSA-N
SMILES
CC(=O)NNC(=O)N1CC2=C(OC3=CC=C(Cl)C=C13)C=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.18 | 100 | |
| Ethanol | 8.29 | 25 with gentle warming |
Preparing Stock Solutions
for SC 19220
The following data is based on the product molecular weight 331.76
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.07 mL | 30.14 mL |
| 5 mM | 0.60 mL | 3.01 mL | 6.03 mL |
| 10 mM | 0.30 mL | 1.51 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Funk Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J.Biol.Chem. 1993 PMID: 8253813
- Sanner Dibenzoxazepine hydrazides as prostaglandin antagonists. Intra-Science Chem.Rept.
- Botella Receptor subtypes involved in dual effects induced by prostaglandin E2 in circular smooth muscle from dog colon. J.Pharmacol.Exp.Ther. 1995 PMID: 7791070
Product Specific Notices for SC 19220
For research use only
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