SB 772077B dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4118
Potent Rho-kinase inhibitor; vasodilator
Key Product Details
Description
Potent Rho-kinase inhibitor; vasodilator
Product Description
SB 772077B dihydrochloride is a potent Rho-kinase (ROCK) inhibitor (IC50 value of approximately 5.6 nM at recombinant human ROCK1 and 2). Decreases pulmonary and systemic arterial blood pressures and increases cardiac output. Exhibits vasodilator activity that is more potent than Y-27632 (Cat. No 1254) or Fasudil (Cat. No. 0541).Licensing Information
Sold for research purposes under agreement from GlaxoSmithKlineProduct Specifications
Molecular Weight
415.28
Formula
C15H18N8O2.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(3S)-1-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-7-yl]carbonyl]-3-pyrrolidinamine dihydrochloride
CAS Number
607373-46-6
PubChem ID
69157798
InChI Key
HSROPTGRSYJPJY-JZGIKJSDSA-N
SMILES
NC1=NON=C1C3=NC2=CN=CC(C(N4CC[C@H](N)C4)=O)=C2N3CC.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 41.53 | 100 | |
| DMSO | 41.53 | 100 |
Preparing Stock Solutions
for SB 772077B dihydrochloride
The following data is based on the product molecular weight 415.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.04 mL | 24.08 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.82 mL |
| 10 mM | 0.24 mL | 1.20 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dhaliwal Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor. J.Pharm.Exp.Ther.
- Doe Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J.Pharmacol.Exp.Ther. 2007 PMID: 17018693
Product Specific Notices for SB 772077B dihydrochloride
For research use only
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