SB 452533

Name: SB 452533
Brand: Tocris Bioscience
SKU: 3265

Tocris Bioscience, part of Bio-Techne | Catalog # 3265

COA / SDS

Potent TRPV1 antagonist

Discontinued Product

3265 has been discontinued. View all TRPV Antagonists products.

Key Product Details

Description:	Potent TRPV1 antagonist
Chemical Name:	N-(2-Bromophenyl)-N'-[2-[ethyl(3-methylphenyl)amino]ethyl]-urea
Purity:	≥98% (HPLC)
Molecular Weight:	376.29

View Full Technical Details for SB 452533

Technical Data
Citations

Biological Activity for SB 452533

SB 452533 is a potent TRPV1 antagonist against capsaicin (pK_b = 7.7), noxious heat and acid-mediated (pIC₅₀ = 7.0) receptor activation (pK_i = 6.22 at the recombinant hTRPV1 receptor). Exhibits analgesic properties.

Licensing Information

Sold for research purposes only under agreement from GlaxoSmithKline

Technical Data for SB 452533

M. Wt	376.29
Formula	C₁₈H₂₂BrN₃O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	459429-39-1
PubChem ID	9842609
InChi Key	IFJYEGJUQIBBQV-UHFFFAOYSA-N
Smiles	CC1=CC(N(CC)CCNC(NC2=CC=CC=C2Br)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for SB 452533

References are publications that support the biological activity of the product.

Weil Conservation of functional and pharmacological properties in the distantly related temperature sensors TRPV1 and TRPM8. Mol.Pharmacol. 2005 PMID: 15911692
Bianchi [³H]A-778317 [1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-ylurea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor. J.Pharmacol.Exp.Ther. 2007 PMID: 17660385
Rami Discovery of small molecule antagonists of TRPV1. Bioorg.Med.Chem.Lett. 2004 PMID: 15203132