SB 415286

Name: SB 415286
Brand: Tocris Bioscience
SKU: 1617

Tocris Bioscience, part of Bio-Techne | Catalog # 1617

Citations (131)

COA / SDS

Potent, selective GSK-3 inhibitor

Key Product Details

Description:	Potent, selective GSK-3 inhibitor
Chemical Name:	3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
Purity:	≥98% (HPLC)
Molecular Weight:	359.73

View Full Technical Details for SB 415286

Technical Data
Citations

Biological Activity for SB 415286

SB 415286 is a potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (K_i = 31 nM for GSK-3α); competes with ATP. Has minimal activity against 24 other protein kinases (IC₅₀ > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for SB 415286

M. Wt	359.73
Formula	C₁₆H₁₀ClN₃O₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	264218-23-7
PubChem ID	4210951
InChi Key	PQCXVIPXISBFPN-UHFFFAOYSA-N
Smiles	OC1=C(Cl)C=C(NC2=C(C(=O)NC2=O)C2=C(C=CC=C2)[N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 415286

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	8.99	25
	DMSO	17.99	50

Preparing Stock Solutions for SB 415286

The following data is based on the product molecular weight 359.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.56 mL	27.80 mL	55.60 mL
2.5 mM	1.11 mL	5.56 mL	11.12 mL
5 mM	0.56 mL	2.78 mL	5.56 mL
25 mM	0.11 mL	0.56 mL	1.11 mL

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References for SB 415286

References are publications that support the biological activity of the product.

Cross Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. J.Neurochem. 2001 PMID: 11279265
Liang and Chuang Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. J.Biol.Chem. 2006 PMID: 17148450
Coghlan Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem.Biol. 2000 PMID: 11033082