SB 290157 trifluoroacetate
Tocris Bioscience, part of Bio-Techne | Catalog # 6860
Potent C3a receptor antagonist
Key Product Details
Description
Potent C3a receptor antagonist
Product Description
SB 290157 trifluoroacetate is a potent C3a receptor antagonist (IC50 values are 27 - 30 nM for C3a-induced Ca2+ mobilization in vitro and ex vivo). Inhibits C3a-induced chemotaxis in human mast cell line. Also inhibits tau hyperphosphorylation in vitro. Displays anti-inflammatory effects in animal models of airway inflammation and arthritis. Also inhibits glucose-induced insulin secretion and ATP production from ex vivo human and mouse pancreatic islets. Also exhibits C3a receptor agonist activity.Product Specifications
Molecular Weight
526.51
Formula
C22H28N4O4.CF3CO2H
Storage
Desiccate at RT
Purity
≥97% (HPLC)
Chemical Name
N2-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate
CAS Number
1140525-25-2
PubChem ID
16760645
InChI Key
ZJRMPPVJAQWGEG-FYZYNONXSA-N
SMILES
NC(NCCC[C@@H](C(O)=O)NC(COCC(C1=CC=CC=C1)C2=CC=CC=C2)=O)=N.FC(F)(C(O)=O)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.65 | 100 |
Preparing Stock Solutions
for SB 290157 trifluoroacetate
The following data is based on the product molecular weight 526.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.90 mL | 9.50 mL | 18.99 mL |
| 5 mM | 0.38 mL | 1.90 mL | 3.80 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.90 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mathieu The C3a receptor antagonist SB 290157 has agonist activity. Immunol.Lett. 2005 PMID: 16154494
- Atanes C3aR and C5aR1 act as key regulators of human and mouse β-cell function. Cell Mol.Life Sci. 2018 PMID: 28921001
- Hu Complement C3a receptor antagonist attenuates tau hyperphosphorylation via glycogen synthase kinase 3β signaling pathways. Eur.J.Pharmacol. 2019 PMID: 30771350
- Ames Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. J.Immunol. 2001 PMID: 11342658
Product Specific Notices for SB 290157 trifluoroacetate
For research use only
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