SB 258585 hydrochloride

Name: SB 258585 hydrochloride
Brand: Tocris Bioscience
SKU: 1961

Tocris Bioscience, part of Bio-Techne | Catalog # 1961

Citations (4)

COA / SDS

Potent, selective 5-HT6 antagonist

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Product Description
Licensing Information
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent, selective 5-HT6 antagonist

View all 5-HT6 Receptor Antagonists »

Product Description

SB 258585 hydrochloride is a potent and selective 5-HT₆ receptor antagonist (pK_i = 8.6); displays > 160-fold selectivity over other 5-HT receptor subtypes.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications

Molecular Weight

523.82

Formula

C₁₈H₂₂IN₃O₃S.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-Iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide hydrochloride

CAS Number

1216468-02-8

PubChem ID

53429667

InChI Key

BFGOZFXMAJBFGI-UHFFFAOYSA-N

SMILES

Cl.COC1=CC=C(NS(=O)(=O)C2=CC=C(I)C=C2)C=C1N1CCN(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	5.24	10
	DMSO	26.19	50

Preparing Stock Solutions for SB 258585 hydrochloride

The following data is based on the product molecular weight 523.82

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.82 mL	19.09 mL	38.18 mL
2.5 mM	0.76 mL	3.82 mL	7.64 mL
5 mM	0.38 mL	1.91 mL	3.82 mL
25 mM	0.08 mL	0.38 mL	0.76 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

East 5-HT₆ receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [¹²⁵I]SB-258585. Synapse 2002 PMID: 12112397
Hirst Characterization of [¹²⁵I]-SB-258585 binding to human recombinant and native 5-HT₆ receptors in rat, pig and human brain tissue. Br.J.Pharmacol. 2000 PMID: 10928963
Bromidge 5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): a potent, selective, and orally bioavailable 5-HT₆ receptor antagonist. J.Med.Chem. 1999 PMID: 9925723