SB 24011
Tocris Bioscience, part of Bio-Techne | Catalog # 8010
Inhibitor of STING-TRIM29 interaction; increases cellular STING levels
Key Product Details
Description
Inhibitor of STING-TRIM29 interaction; increases cellular STING levels
Product Description
SB 24011 is an inhibitor of STING-TRIM29 interaction (IC50 = 3.85 μM in vitro). SB 24011 binds to STING and inhibits TRIM29-E3 ligase interaction to increase cellular STING levels. In syngeneic mouse models, SB 24011 dose-dependently reduces CT26 and B16F10 tumor volumes when co-admistered with cGAMP.Product Specifications
Molecular Weight
614.70
Formula
C34H38N4O7
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide
CAS Number
1497415-41-4
PubChem ID
171038176
InChI Key
UZVHJOMTRTYDKL-BHDXBOSCSA-N
SMILES
CC([C@H]1N(C2=C(C=C(C=C2)C(NC[C@@H]3CCCO3)=O)[N+]([O-])=O)C=C(N(C1=O)CC4=CC=C(C=C4)O)CC5=CC=C(C=C5)OC)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 61.47 | 100 |
Preparing Stock Solutions
for SB 24011
The following data is based on the product molecular weight 614.70
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.63 mL | 8.13 mL | 16.27 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 10 mM | 0.16 mL | 0.81 mL | 1.63 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cho Targeted protein upregulation of STING for boosting the efficacy of immunotherapy. Angew.Chem.Int.Ed.Engl. 2023 PMID: 36827625
Product Specific Notices for SB 24011
For research use only
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