SB 224289 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1221
Selective 5-HT1B antagonist
Product Description
SB 224289 hydrochloride is a selective 5-HT1B receptor antagonist (pKi = 8.2). Displays > 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo.Licensing Information
Sold with the permission of GlaxoSmithKlineProduct Specifications
Molecular Weight
557.09
Formula
C32H32N4O3.HCl
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine hydrochloride
CAS Number
180084-26-8
PubChem ID
11226716
InChI Key
GKGKBZYMDILCOF-UHFFFAOYSA-N
SMILES
O=C(C5=CC=C(C6=CC=C(C7=NOC(C)=N7)C=C6C)C=C5)N2C1=CC3=C(OCC43CCN(CC4)C)C=C1CC2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.57 | 10 with gentle warming |
Preparing Stock Solutions
for SB 224289 hydrochloride
The following data is based on the product molecular weight 557.09
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.95 mL | 89.75 mL | 179.50 mL |
| 0.5 mM | 3.59 mL | 17.95 mL | 35.90 mL |
| 1 mM | 1.80 mL | 8.98 mL | 17.95 mL |
| 5 mM | 0.36 mL | 1.80 mL | 3.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Selkirk SB-224289 - a novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity. Br.J.Pharmacol. 1998 PMID: 9776361
- Hagan Stimulation of 5-HT1B receptors causes hypothermia in the guinea-pig. Eur.J.Pharmacol. 1997 PMID: 9274976
- Roberts Differential effects of 5-HT1B/1D receptor antagonists in dorsal and median raphe innervated brain regions. Eur.J.Pharmacol. 1998 PMID: 9652357
- Gaster The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine (SB-224289) potently blocks terminal 5-HT J.Med.Chem. 1998 PMID: 9548813
Product Specific Notices for SB 224289 hydrochloride
For research use only
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