SB 218795

Name: SB 218795
Brand: Tocris Bioscience
SKU: 1376

Tocris Bioscience, part of Bio-Techne | Catalog # 1376

Citations (6)

COA / SDS

Potent, selective non-peptide NK3 antagonist

Discontinued Product

1376 has been discontinued. View all NK3 Receptor Antagonists products.

Key Product Details

Description:	Potent, selective non-peptide NK₃ antagonist
Chemical Name:	(R)-[[2-Phenyl-4-quinolinyl)carbonyl]amino]-methyl ester benzeneacetic acid
Purity:	≥99% (HPLC)
Molecular Weight:	396.44

View Full Technical Details for SB 218795

Technical Data
Citations

Biological Activity for SB 218795

SB 218795 is a potent, selective and competitive non-peptide NK₃ receptor antagonist (K_i = 13 nM at hNK₃). Displays 90-fold and 7000-fold selectivity over hNK₂ and hNK₁ receptors respectively. Active in vivo, inhibiting agonist-induced pupillary constriction.

Licensing Information

Sold under license

Technical Data for SB 218795

M. Wt	396.44
Formula	C₂₅H₂₀N₂O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	174635-53-1
PubChem ID	6604858
InChi Key	IUMQXQJZIHWLIN-HSZRJFAPSA-N
Smiles	COC(=O)[C@H](NC(=O)C1=C2C=CC=CC2=NC(=C1)C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SB 218795

References are publications that support the biological activity of the product.

Medhurst In vitro and in vivo characterization of NK₃ receptors in the rabbit eye by use of selective non-peptide NK₃ receptor antagonists. Br.J.Pharmacol. 1997 PMID: 9351503
Giardina Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework. J.Med.Chem. 1997 PMID: 9191956