Sarpogrelate hydrochloride

Name: Sarpogrelate hydrochloride
Brand: Tocris Bioscience
SKU: 3739

Tocris Bioscience, part of Bio-Techne | Catalog # 3739

Citations (3)

COA / SDS

Selective 5-HT2A antagonist

Key Product Details

Description:	Selective 5-HT_2A antagonist
Alternative Names:	MCI 9042
Chemical Name:	Succinic acid mono-(1-dimethylaminomethyl-2-(2-[2-(3-methoxyphenyl)ethyl]phenoxy)ethyl) ester hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	465.97

View Full Technical Details for Sarpogrelate hydrochloride

Technical Data
Citations

Biological Activity for Sarpogrelate hydrochloride

Sarpogrelate hydrochloride is a selective 5-HT_2A receptor antagonist (pK_i values are 8.52, 7.43 and 6.57 for 5-HT_2A, 5-HT_2C and 5-HT_2B receptors respectively). Displays selectivity over 5-HT₁, 5-HT₃, 5-HT₄ H₁, H₂, M₃, α₁-adrenergic, α₂-adrenergic and β-adrenergic receptors. Displays cardioprotective activity in vivo.

Technical Data for Sarpogrelate hydrochloride

M. Wt	465.97
Formula	C₂₄H₃₁NO₆.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	135159-51-2
PubChem ID	444005
InChi Key	POQBIDFFYCYHOB-UHFFFAOYSA-N
Smiles	O=C(CCC(O)=O)OC(CN(C)C)COC1=CC=CC=C1CCC2=CC(OC)=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sarpogrelate hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	11.65	25
	DMSO	46.6	100

Preparing Stock Solutions for Sarpogrelate hydrochloride

The following data is based on the product molecular weight 465.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.73 mL	21.46 mL
5 mM	0.43 mL	2.15 mL	4.29 mL
10 mM	0.21 mL	1.07 mL	2.15 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for Sarpogrelate hydrochloride

References are publications that support the biological activity of the product.

Brasil Blockade of 5-HT(2A) receptors by sarpogrelate protects the heart against myocardial infarction in rats. J.Cardiovasc.Pharmacol.Ther. 2002 PMID: 12000979
Nishiyama Acute effects of sarpogrelate, a 5-HT_2A receptor antagonist on cytokine production in endotoxin shock model of rats. Eur.J.Pharmacol. 2009 PMID: 19318092
Rashid Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT₂ antagonist, to human 5-HT_2A, 5-HT_2B and 5-HT_2C receptor subtypes by molecular modeling. Life Sci. 2003 PMID: 12738034