Sarafotoxin S6c

Name: Sarafotoxin S6c
Brand: Tocris Bioscience
SKU: 1175

Tocris Bioscience, part of Bio-Techne | Catalog # 1175

Citations (8)

COA / SDS

Selective ETB agonist

Discontinued Product

1175 has been discontinued. View all Endothelin ETB Receptor Agonists products.

Key Product Details

Description:	Selective ET_B agonist
Purity:	≥95% (HPLC)
Molecular Weight:	2516

View Full Technical Details for Sarafotoxin S6c

Technical Data
Citations

Biological Activity for Sarafotoxin S6c

Sarafotoxin S6c is a highly selective ET_B endothelin receptor agonist (K_i values are 0.29 and 28000 nM at ET_B and ET_A receptors respectively).

Technical Data for Sarafotoxin S6c

M. Wt	2516
Formula	C₁₀₃H₁₄₇N₂₇O₃₇S₅
Single Letter Sequence	CTCNDMTDEECLNFCHQDVIW (Modifications: Disulfide bridges: 1-15, 3-11)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	121695-87-2
PubChem ID	71456935
InChi Key	LXPHPKVWHQLBBA-JHOSIGDNSA-N
Smiles	[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Sarafotoxin S6c

References are publications that support the biological activity of the product.

Williams Characterization of cloned human endothelin receptors. Life Sci. 1993 PMID: 8336519
Miasiro Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL 1620 in the ileum. J.Cardiovasc.Pharmacol. 1998 PMID: 9595431
Williams Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes. Biochem.Biophys.Res.Commun. 1991 PMID: 1850245
Matsuo Effects of sarafotoxin S6c on antidiuresis and NE overflow induced by stimulation of renal nerves in anesthetized dogs. J.Pharmacol.Exp.Ther. 1997 PMID: 9023305

Sarafotoxin S6c

Tocris Bioscience, part of Bio-Techne | Catalog # 1175

Key Product Details

Biological Activity for Sarafotoxin S6c

Technical Data for Sarafotoxin S6c

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Sarafotoxin S6c

Product Documents for Sarafotoxin S6c

COA

Certificate of Analysis

SDS

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