SAR 7334

Name: SAR 7334
Brand: Tocris Bioscience
SKU: 5831

Tocris Bioscience, part of Bio-Techne | Catalog # 5831

Citations (26)

COA / SDS

Potent TRPC6 inhibitor

Key Product Details

Description:	Potent TRPC6 inhibitor
Chemical Name:	4-[[(1R,2R)-2-[(3R)-3-Amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	440.79

View Full Technical Details for SAR 7334

Technical Data
Citations

Biological Activity for SAR 7334

SAR 7334 is a potent TRPC6 inhibitor (IC₅₀ values are 9.5, 226 and 282 nM for TRPC6, TRPC7 and TRPC3-mediated Ca²⁺ influx). Exhibits no significant activity at TRPC4 and TRPC5 channels. Suppresses TRPC6-dependent acute hypoxic pulmonary vasoconstriction (HPV) in the isolated perfused mouse lung. Orally bioavailable.

Technical Data for SAR 7334

M. Wt	440.79
Formula	C₂₁H₂₂ClN₃O.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1333207-63-8
PubChem ID	78357800
InChi Key	LFMYIKNZNTZSJX-IQJQELQDSA-N
Smiles	N[C@@H]1CCCN([C@@H]2CC3=CC=CC=C3[C@H]2OC4=C(C=C(C#N)C=C4)Cl)C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SAR 7334

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	44.08	100
	DMSO	44.08	100

Preparing Stock Solutions for SAR 7334

The following data is based on the product molecular weight 440.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.34 mL	22.69 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
10 mM	0.23 mL	1.13 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for SAR 7334

References are publications that support the biological activity of the product.

Maier Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br.J.Pharmacol. 2015 PMID: 25847402