Santacruzamate A

Name: Santacruzamate A
Brand: Tocris Bioscience
SKU: 7191

Tocris Bioscience, part of Bio-Techne | Catalog # 7191

Citations (1)

COA / SDS

Highly potent and selective HDAC2 inhibitor

Key Product Details

Description:	Highly potent and selective HDAC2 inhibitor
Chemical Name:	Ethyl N-[4-oxo-4-[(2-phenylethyl)amino]butyl]carbamate
Purity:	≥98% (HPLC)
Molecular Weight:	278.35

View Full Technical Details for Santacruzamate A

Technical Data
Citations

Biological Activity for Santacruzamate A

Santacruzamate A is a highly potent and selective histone deactylase 2 (HDAC2) inhibitor (IC₅₀ = 112 - 119 pM). Also inhibits HDAC6 in nanomolar range (IC₅₀ = 433 nM). Displays >3500 fold selectivity for HDAC2 over HDAC6, and >8500-fold selectivity over HDAC4 (IC₅₀ >1 μM for HDAC4). Inhibits growth of HuT-78 cutaneous T-cell lymphoma cell line. Identified as targeting human host proteins that interact with SARS-CoV-2.

Compound Libraries for Santacruzamate A

Santacruzamate A is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Santacruzamate A

M. Wt	278.35
Formula	C₁₅H₂₂N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1477949-42-0
PubChem ID	72946782
InChi Key	HTOYBIILVCHURC-UHFFFAOYSA-N
Smiles	CCOC(=O)NCCCC(=O)NCCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Santacruzamate A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	27.84	100

Preparing Stock Solutions for Santacruzamate A

The following data is based on the product molecular weight 278.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.59 mL	17.96 mL	35.93 mL
5 mM	0.72 mL	3.59 mL	7.19 mL
10 mM	0.36 mL	1.80 mL	3.59 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References for Santacruzamate A

References are publications that support the biological activity of the product.

Gordon A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 PMID: 32353859
Pavlik Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J.Nat.Prod. 2013 PMID: 24164245