Saclofen

Name: Saclofen
Brand: Tocris Bioscience
SKU: 0246

Tocris Bioscience, part of Bio-Techne | Catalog # 0246

Citations (141)

COA / SDS

Selective GABAB antagonist

Key Product Details

Description:	Selective GABA_B antagonist
Chemical Name:	(RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
Purity:	≥98% (HPLC)
Molecular Weight:	249.72

View Full Technical Details for Saclofen

Technical Data
Citations

Biological Activity for Saclofen

Saclofen is a selective antagonist at GABA_B receptors.

Technical Data for Saclofen

M. Wt	249.72
Formula	C₉H₁₂ClNO₃S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	125464-42-8
PubChem ID	122150
InChi Key	JYLNVJYYQQXNEK-UHFFFAOYSA-N
Smiles	NCC(CS(O)(=O)=O)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Saclofen

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	2.5	10

Preparing Stock Solutions for Saclofen

The following data is based on the product molecular weight 249.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	40.04 mL	200.22 mL	400.45 mL
0.5 mM	8.01 mL	40.04 mL	80.09 mL
1 mM	4.00 mL	20.02 mL	40.04 mL
5 mM	0.80 mL	4.00 mL	8.01 mL

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References for Saclofen

References are publications that support the biological activity of the product.

Jane Use of the neonatal rat spinal cord in studies of the GABA_B receptor. GABA<sub>B</sub> receptors in Mammalian Function.
Bowery GABA_B receptors and their significance in mammalian pharmacology. TiPS 1989 PMID: 2559518