(S)-(-)-Bay K 8644
Tocris Bioscience, part of Bio-Techne | Catalog # 1546
CaV1.x activator; (S)-(-)-enantiomer of (±)-Bay K 8644
Key Product Details
Description
CaV1.x activator; (S)-(-)-enantiomer of (±)-Bay K 8644
Product Description
(S)-(-)-Bay K 8644 is a L-type Ca2+-channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo.Racemate and (R)-(+)-Enantiomer also available.
Product Specifications
Molecular Weight
356.30
Formula
C16H15F3N2O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
CAS Number
98625-26-4
PubChem ID
6603728
InChI Key
ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
SMILES
O=C(OC)C1=C(C)NC(C)=C([N+]([O-])=O)[C@H]1[C@]2=CC=CC=C2C(F)(F)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.63 | 100 | |
| Ethanol | 35.63 | 100 |
Preparing Stock Solutions
for (S)-(-)-Bay K 8644
The following data is based on the product molecular weight 356.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.81 mL | 14.03 mL | 28.07 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.61 mL |
| 10 mM | 0.28 mL | 1.40 mL | 2.81 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- O'Neill and Bolger Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644. Brain Res.Bull. 1988 PMID: 2465070
- Ravens and Schopper Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch.Pharmacol. 1990 PMID: 1692975
- Franckowiak The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels. Eur.J.Pharmacol. 1985 PMID: 2412855
Product Specific Notices for (S)-(-)-Bay K 8644
For research use only
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