RWJ 67657

Tocris Bioscience, part of Bio-Techne | Catalog # 2999

Potent, selective p38α and p38β inhibitor
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Key Product Details

Description

Potent, selective p38α and p38β inhibitor

View all p38 Inhibitors »

Product Description

RWJ 67657 is a selective p38α and p38β inhibitor (IC50 values are 1 and 11 μM respectively) that displays no activity at p38γ, p38δ and a range of other kinases. Potently inhibits TNF-α and IL-1β release (IC50 values are 3 and 11 nM respectively) and suppresses HIV-1 replication in T cells in vitro. Displays cardioprotective and anti-inflammatory activity in vivo. Orally active.

Product Specifications

Molecular Weight

425.50

Formula

C27H24FN3O

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol

CAS Number

215303-72-3

PubChem ID

3008319

InChI Key

QSUSKMBNZQHHPA-UHFFFAOYSA-N

SMILES

FC(C=C4)=CC=C4C(N=C(C#CCCO)N2CCCC3=CC=CC=C3)=C2C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.55 100
Ethanol 42.55 100

Preparing Stock Solutions for RWJ 67657

The following data is based on the product molecular weight 425.50

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.75 mL 23.50 mL
5 mM 0.47 mL 2.35 mL 4.70 mL
10 mM 0.24 mL 1.18 mL 2.35 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for RWJ 67657

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RWJ 67657

For research use only

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