RWJ 50271

Name: RWJ 50271
Brand: Tocris Bioscience
SKU: 4227

Tocris Bioscience, part of Bio-Techne | Catalog # 4227

Citations (5)

COA / SDS

Inhibitor of LFA-1/ICAM mediated cell adhesion

Discontinued Product

4227 has been discontinued. View all Integrin Receptor Inhibitors products.

Key Product Details

Description:	Inhibitor of LFA-1/ICAM mediated cell adhesion
Chemical Name:	N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	410.41

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Technical Data
Citations

Biological Activity for RWJ 50271

RWJ 50271 is a selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC₅₀ = 5 μM in HL60 cells).

Technical Data for RWJ 50271

M. Wt	410.41
Formula	C₁₈H₁₇F₃N₄O₂S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	162112-37-0
PubChem ID	9953357
InChi Key	HOFGTYCLOKDAES-UHFFFAOYSA-N
Smiles	CC1=C(C(NCCCO)=O)C=NN1C2=NC(C3=CC(C(F)(F)F)=CC=C3)=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for RWJ 50271

References are publications that support the biological activity of the product.

Sanfilippo Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. J.Med.Chem. 1995 PMID: 7707308

RWJ 50271

Tocris Bioscience, part of Bio-Techne | Catalog # 4227

Key Product Details

Biological Activity for RWJ 50271

Technical Data for RWJ 50271

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for RWJ 50271

Product Documents for RWJ 50271

COA

Certificate of Analysis

SDS

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