Rufinamide
Tocris Bioscience, part of Bio-Techne | Catalog # 3828
Prolongs inactivation of sodium channels; anticonvulsant
Key Product Details
Description
Prolongs inactivation of sodium channels; anticonvulsant
Alternative Names
CGP 33101
Product Description
Rufinamide is a board spectrum anticonvulsant. Prolongs the inactivation of sodium channels and limits the frequency of action potential firing in cultured and acutely isolated neurons. Displays anticonvulsive activity in a range of animal seizure models.Product Specifications
Molecular Weight
238.19
Formula
C10H8F2N4O
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
CAS Number
106308-44-5
PubChem ID
129228
InChI Key
POGQSBRIGCQNEG-UHFFFAOYSA-N
SMILES
O=C(N)C1=CN(CC2=C(F)C=CC=C2F)N=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.82 | 100 |
Preparing Stock Solutions
for Rufinamide
The following data is based on the product molecular weight 238.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.20 mL | 20.99 mL | 41.98 mL |
| 5 mM | 0.84 mL | 4.20 mL | 8.40 mL |
| 10 mM | 0.42 mL | 2.10 mL | 4.20 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Arroyo Rufinamide. Neurotherapeutics 2007 PMID: 17199032
- White The anticonvulsant profile of rufin. (CGP 33101) in rodent seizure models. Epilepsia 2008 PMID: 18325020
- Rogawski Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 2006 PMID: 16621450
Product Specific Notices for Rufinamide
For research use only
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