RuBi GABA trimethylphosphine

Name: RuBi GABA trimethylphosphine
Brand: Tocris Bioscience
SKU: 4709

Tocris Bioscience, part of Bio-Techne | Catalog # 4709

Citations (7)

COA / SDS

Caged GABA; inhibits neural activity

Key Product Details

Description:	Caged GABA; inhibits neural activity
Alternative Names:	RuBi-GABA-PMe₃
Chemical Name:	(bis(2,2'-Bipyridine-N,N')trimethylphosphine)-4-aminobutyric acid ruthenium complex sodium hexafluorophosphate salt
Molecular Weight:	904.56

View Full Technical Details for RuBi GABA trimethylphosphine

Technical Data
Citations

Biological Activity for RuBi GABA trimethylphosphine

RuBi GABA trimethylphosphine is a modified version of RuBi-GABA (Cat. No. 3400). Suppresses cortical local field potential (LFP) activity in anesthetized mice after activation with a blue laser pulse (473 nm); inhibits neural activity.

Licensing Information

Sold under licence from Columbia University

Technical Data for RuBi GABA trimethylphosphine

M. Wt	904.56
Formula	C₂₇H₃₃N₅O₂PRu.PF₆.NaPF₆
Storage	Store at -20°C
InChi Key	AYYRUPXLUXSCBC-UHFFFAOYSA-N
Smiles	[F-][P+5]([F-])([F-])([F-])([F-])[F-].[F-][P+5]([F-])([F-])([F-])([F-])[F-].CP(C)([Ru+2]12([N]3=CC=CC=C3C4=CC=CC=[N]14)([N]5=CC=CC=C5C6=CC=CC=[N]26)NCCCC([O-])=O)C.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RuBi GABA trimethylphosphine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	45.23	50

Preparing Stock Solutions for RuBi GABA trimethylphosphine

The following data is based on the product molecular weight 904.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.21 mL	11.06 mL	22.11 mL
2.5 mM	0.44 mL	2.21 mL	4.42 mL
5 mM	0.22 mL	1.11 mL	2.21 mL
25 mM	0.04 mL	0.22 mL	0.44 mL

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References for RuBi GABA trimethylphosphine

References are publications that support the biological activity of the product.

Filevich RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity. Photochem.Photobiol.Sci. 2013 PMID: 23674097
Lopes-dos-Santos In vivo photorelease of GABA in the mouse cortex. Braz.J.Med.Biol.Res. 2011 PMID: 21755263