RS 504393

Tocris Bioscience, part of Bio-Techne | Catalog # 2517

Highly selective CCR2 chemokine receptor antagonist
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Key Product Details

Description

Highly selective CCR2 chemokine receptor antagonist

View all Chemokine Receptor Antagonists »

Product Description

RS 504393 is an extremely selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.

Product Specifications

Molecular Weight

417.50

Formula

C25H27N3O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one

CAS Number

300816-15-3

PubChem ID

9953769

InChI Key

ODNICNWASXKNNQ-UHFFFAOYSA-N

SMILES

CC1=C(CCN2CCC3(CC2)OC(=O)NC2=C3C=C(C)C=C2)N=C(O1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.17 10

Preparing Stock Solutions for RS 504393

The following data is based on the product molecular weight 417.50

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.95 mL 119.76 mL 239.52 mL
0.5 mM 4.79 mL 23.95 mL 47.90 mL
1 mM 2.40 mL 11.98 mL 23.95 mL
5 mM 0.48 mL 2.40 mL 4.79 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for RS 504393

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RS 504393

For research use only

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