Ro 6842262
Tocris Bioscience, part of Bio-Techne | Catalog # 5913
Potent LPA1 antagonist
Key Product Details
Description
Potent LPA1 antagonist
Product Description
Ro 6842262 is a potent LPA1 antagonist (IC50 = 25 nM). Exhibits >1,200-fold selectivity for LPA1 over LPA3. Attenuates NHLF human lung fibroblast cell proliferation and contraction in vitro. Also reduces plasma histamine levels in mouse LPA-challenge model. Orally bioavailable.Product Specifications
Molecular Weight
482.53
Formula
C28H26N4O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-[4'-[4-Methyl-5-[[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1'-biphenyl]-4-yl]cyclopropanecarboxylic acid
CAS Number
1396006-71-5
PubChem ID
71265339
InChI Key
PXQUHYSYFWQRMF-LJQANCHMSA-N
SMILES
CC1=C(NC(O[C@H](C)C2=CC=CC=C2)=O)N(C3=CC=C(C4=CC=C(C5(CC5)C(O)=O)C=C4)C=C3)N=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.25 | 100 | |
| Ethanol | 9.65 | 20 |
Preparing Stock Solutions
for Ro 6842262
The following data is based on the product molecular weight 482.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.07 mL | 10.36 mL | 20.72 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.14 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.07 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Qian Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts. J.Med.Chem. 2012 PMID: 22894757
Product Specific Notices for Ro 6842262
For research use only
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