Ro 67-7476
Tocris Bioscience, part of Bio-Techne | Catalog # 4346
Positive allosteric modulator of mGlu1 receptors
Key Product Details
Description
Positive allosteric modulator of mGlu1 receptors
Product Description
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. Potentiates glutamate-induced calcium release (EC50 = 60.1 nM at rat mGluR1a). Displays no activity at human mGlu1 receptors.Product Specifications
Molecular Weight
319.39
Formula
C17H18FNO2S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine
CAS Number
298690-60-5
PubChem ID
32681978
InChI Key
DAEHFYNGSSBGSS-KRWDZBQOSA-N
SMILES
FC(C=C2)=CC=[C@@]2[C@@H]1CCCN1S(C3=CC=C(C)C=C3)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.94 | 100 |
Preparing Stock Solutions
for Ro 67-7476
The following data is based on the product molecular weight 319.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.65 mL | 31.31 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Knoflach Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc.Natl.Acad.Sci.USA 2001 PMID: 11606768
- Hemstapat A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 2006 PMID: 16645124
Product Specific Notices for Ro 67-7476
For research use only
Loading...
Loading...