Ro 67-4853
Tocris Bioscience, part of Bio-Techne | Catalog # 4347
Positive allosteric modulator of group I mGlu receptors
Key Product Details
Description
Positive allosteric modulator of group I mGlu receptors
Product Description
Ro 67-4853 is a positive allosteric modulator of mGlu group I receptors (pEC50 value is 7.16 for the rat mGlu1a receptor). Exhibits activity at all group I receptors, including human and rat mGlu1 and rat mGlu5. Enhances the effects of (S)-DHPG in CA3 neurons (EC50 = 95 nM).Product Specifications
Molecular Weight
325.36
Formula
C19H19NO4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester
CAS Number
302841-89-0
PubChem ID
9949202
InChI Key
RQBUXEUMZZQUFY-UHFFFAOYSA-N
SMILES
O=C(NC(OCCCC)=O)C2C3=C(C=CC=C3)OC1=CC=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.54 | 100 |
Preparing Stock Solutions
for Ro 67-4853
The following data is based on the product molecular weight 325.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.07 mL | 15.37 mL | 30.74 mL |
| 5 mM | 0.61 mL | 3.07 mL | 6.15 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.07 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hempstapat A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 2006 PMID: 16645124
- Knoflach Positive allosteric modulators of metabotropic glutamate receptor: Characterizationn, mechanism of action, and binding site. Proc.Natl.Acad.Sci. 2001 PMID: 11606768
Product Specific Notices for Ro 67-4853
For research use only
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