Ro 64-5229

Name: Ro 64-5229
Brand: Tocris Bioscience
SKU: 2913

Tocris Bioscience, part of Bio-Techne | Catalog # 2913

Citations (4)

COA / SDS

Selective, non-competitive mGlu2 antagonist

Key Product Details

Description:	Selective, non-competitive mGlu₂ antagonist
Chemical Name:	(Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole
Purity:	≥98% (HPLC)
Molecular Weight:	352.26

View Full Technical Details for Ro 64-5229

Technical Data
Citations

Biological Activity for Ro 64-5229

Ro 64-5229 is a selective, non-competitive mGlu₂ antagonist. Inhibits GTPγ³⁵S binding to mGlu₂-containing membranes (IC₅₀ = 0.11 μM).

Compound Libraries for Ro 64-5229

Ro 64-5229 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ro 64-5229

M. Wt	352.26
Formula	C₁₇H₁₉Cl₂N₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	246852-46-0
PubChem ID	10428048
InChi Key	STCVFKBRXOEQRF-YBEGLDIGSA-N
Smiles	ClC1=CC=CC(Cl)=C1/C(OC3CCCCCC3)=C/N2N=CN=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ro 64-5229

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.23	100
	ethanol	35.23	100

Preparing Stock Solutions for Ro 64-5229

The following data is based on the product molecular weight 352.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.19 mL	28.39 mL
5 mM	0.57 mL	2.84 mL	5.68 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References for Ro 64-5229

References are publications that support the biological activity of the product.

Brauner-Osbourne Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Curr.Drug Targets. 2007 PMID: 17266540
Kolczewski Synthesis of heterocyclic enol ethers and their use as a group 2 metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett. 1999 PMID: 10465539