Ro 32-0432 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1587
Potent, orally active PKC inhibitor
Key Product Details
Description
Potent, orally active PKC inhibitor
Product Description
Ro 32-0432 hydrochloride is a selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Orally available and prevents T cell chronic inflammation in vivo.Product Specifications
Molecular Weight
489.01
Formula
C28H28N4O2.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride
CAS Number
1781828-85-0
PubChem ID
70346044
InChI Key
HSPRASOZRZDELU-LMOVPXPDSA-N
SMILES
O=C(N1)C(C2=C6N(CC[C@H](CN(C)C)C6)C3=CC=CC=C23)=C(C(C5=C4C=CC=C5)=CN4C)C1=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.89 | 10 with gentle warming |
Preparing Stock Solutions
for Ro 32-0432 hydrochloride
The following data is based on the product molecular weight 489.01
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.45 mL | 102.25 mL | 204.49 mL |
| 0.5 mM | 4.09 mL | 20.45 mL | 40.90 mL |
| 1 mM | 2.04 mL | 10.22 mL | 20.45 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.09 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Birchall Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J.Pharmacol.Exp.Ther. 1994 PMID: 8114006
- Wilkinson Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem.J. 1993 PMID: 8373348
Product Specific Notices for Ro 32-0432 hydrochloride
For research use only
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