Ro 32-0432 hydrochloride

Name: Ro 32-0432 hydrochloride
Brand: Tocris Bioscience
SKU: 1587

Tocris Bioscience, part of Bio-Techne | Catalog # 1587

Citations (3)

COA / SDS

Potent, orally active PKC inhibitor

Key Product Details

Description:	Potent, orally active PKC inhibitor
Chemical Name:	3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	489.01

View Full Technical Details for Ro 32-0432 hydrochloride

Technical Data
Citations

Biological Activity for Ro 32-0432 hydrochloride

Ro 32-0432 hydrochloride is a selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca²⁺ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Orally available and prevents T cell chronic inflammation in vivo.

Technical Data for Ro 32-0432 hydrochloride

M. Wt	489.01
Formula	C₂₈H₂₈N₄O₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1781828-85-0
PubChem ID	70346044
InChi Key	HSPRASOZRZDELU-LMOVPXPDSA-N
Smiles	O=C(N1)C(C2=C6N(CC[C@H](CN(C)C)C6)C3=CC=CC=C23)=C(C(C5=C4C=CC=C5)=CN4C)C1=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ro 32-0432 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.89	10 with gentle warming

Preparing Stock Solutions for Ro 32-0432 hydrochloride

The following data is based on the product molecular weight 489.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.45 mL	102.25 mL	204.49 mL
0.5 mM	4.09 mL	20.45 mL	40.90 mL
1 mM	2.04 mL	10.22 mL	20.45 mL
5 mM	0.41 mL	2.04 mL	4.09 mL

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References for Ro 32-0432 hydrochloride

References are publications that support the biological activity of the product.

Birchall Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J.Pharmacol.Exp.Ther. 1994 PMID: 8114006
Wilkinson Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem.J. 1993 PMID: 8373348