RO-275

Tocris Bioscience, part of Bio-Techne | Catalog # 8977

Potent and selective HCN1 inhibitor
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Key Product Details

Description

Potent and selective HCN1 inhibitor

View all HCN Channel Inhibitors »

Product Description

RO-275 is a potent and selective HCN1 (hyperpolarization-activated cyclic-nucleotide-gated channel 1) inhibitor (IC50 = 46 nM). It shows <100-fold selectivity over HCN2, HCN3 and HCN4. In vivo, RO-275 improves performance in a translationally relevant touchscreen task of working memory (TUNL) in rats. RO-275 is orally bioavailable and brain-penetrant.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the RO-275 probe summary on the SGC website.

Product Specifications

Molecular Weight

351.79

Formula

C18H14ClN5O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-((2-Chloro-3-methylpyridin-4-yl)ethynyl)-5-methyl-1-(pyridin-3-yl)-1H-imidazole-2-carboxamide

CAS Number

2648837-04-9

PubChem ID

156441547

InChI Key

STQKUEFQEVDNLU-UHFFFAOYSA-N

SMILES

O=C(C1=NC(C#CC2=C(C)C(Cl)=NC=C2)=C(C)N1C3=CC=CN=C3)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.59 50

Preparing Stock Solutions for RO-275

The following data is based on the product molecular weight 351.79

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.69 mL 28.43 mL 56.85 mL
2.5 mM 1.14 mL 5.69 mL 11.37 mL
5 mM 0.57 mL 2.84 mL 5.69 mL
25 mM 0.11 mL 0.57 mL 1.14 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for RO-275

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RO-275

For research use only

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